Let Dawn wait on you at the Lung Association-MIRC Boston Pizza fundraiser!

The faculty at MIRC are doing some fundraising with the Lung Association to raise money for a studentship in Lung Health. MIRC has many researchers performing cutting edge research in lung disease (e.g. asthma, lung cancer, COPD, pneumonia) but lung research is seriously underfunded in Canada. We want to fix this by training more young people to contribute to lung health and this studentship is step one. Bring your friends & family, have dinner and support the important work our trainees are doing in lung health!

Flyer - Boston Pizza Celebrity Server Night

Undergraduate positions for 2014/2015 filled.

Thank you for your interest in our lab but unfortunately all undergraduate positions for the  2014/2015 school year have been filled. We do not take volunteers (see our FAQ page for a detailed explanation as to why). In general we fill positions about 6-12 mo in advance. Thank you for your interest and best of luck in your search.

The Bowdish lab is on a roll!

This past month has been very productive in the Bowdish laboratory, with many triumphs achieved by it’s industrious members.

Firstly, a big congratulation goes to Kyle Novakowski, the Bowdish 2013-10-17 23.42.39lab’s newest PhD student. Following a lot of hard work, determination and great dedication to his Masters project, Kyle successfully passed his transfer exam on July 7 and has officially begun his seemingly endless exciting pursuit for a PhD. Good luck to Kyle in continuing his interesting investigation on the regulation and function of MARCO!

 

Dessi Loukov presents her undergraduate work in the Bowdish lab at the 1st annual Perey Symposium, convinces everyone she's a senior PhD student and brings home the Faculty choice award for best speed poster presentation.

Dessi Loukov presents her undergraduate work in the Bowdish lab at the 1st annual Perey Symposium, convinces everyone she’s a senior PhD student and brings home the Faculty choice award for best speed poster presentation.

Next up is Dessi Loukov, who is currently an undergraduate but come September will be the Bowdish lab’s 4th PhD student. At the 1st annual MIRC Perey Symposium held on June 19, Dessi impressed faculty and trainees with her educational and enthusiastic speed poster presentation on modulating the immune system to potentially reverse age-associated inflammation. Dessi was awarded a travel award as a result of her superb presentation skills. Kudos also to Fan Fei (PhD candidate) and Avee Naidoo (MSc candidate) who gave excellent speed poster talks and Dr. Chris Verschoor who gave an excellent oral presentation.  Who knew that research in inflammation could be so exciting? The Bowdish lab, that’s who!

One PhD candidate who deserves great recognition for his recent successes is Mike Dorrington. Not only was Mike awarded with a prestigious and well-deserved Canadian Lung Association & Canadian Thoracic Studentship, but he additionally achieved received The Ruth and Wilson Tafts Prize for Immunology for having the best paper published in a peer-reviewed journal in 2013. Geez Mike, save some awards for the rest of us. These awards will be used to further fund his fascinating work on the role of macrophages – clearly, the best cell around – in recognition and clearance of Streptococcus pneumoniae in the upper respiratory tract. Congratulations Mike!

At the celebration of Mike's first first author publication. Although Dawn is mostly happy for Mike, she is also slightly nervous that she might be about to lose an eye when the champagne is opened.

At the celebration of Mike’s first first author publication. Although Dawn is mostly happy for Mike, she is also slightly nervous that she might be about to lose an eye when the champagne is opened.

Then, there’s Dr. Chris Verschoor, the lab’s most productive and well-rounded member. Chris’ paper entitled, “Alterations to the frequency and function of peripheral blood monocytes and associations with chronic disease in the advanced-age, frail elderly“, was recently accepted into the PLoS one. If you’re interested in changes in monocyte populations with age – I mean, who isn’t? – keep a look out for Chris’ article in the next issue of PLoS one . Way to go Chris on this well-deserved publication!

Chris-sm

 

<- Manuscipt accepted = happy post-doc.

 

 

And last, but definitely not least, the lab takes great pleasure in congratulating our passionate leader, Dr. Dawn Bowdish, who has been awarded tenure and a promotion to Associate Professor effective as of July 1, 2014. This accomplishment is a fitting acknowledgement of Dawn’s exceptional work, devotion and academic contributions to research in the field of macrophage biology. In addition to her promotion and tenure, Dawn recently received a Best Teacher Award in the Department of Pathology for excellence in undergraduate teaching and graduate supervision. Well-done Dawn!

Dawn receives the Pathology & Molecular Medicine Department's best teacher award for her undergraduate and graduate supervision. Dr. Murray Potter, the education co-ordinator and Dr. Fiona Smaill, the chair, present her with the award.

Dawn receives the Pathology & Molecular Medicine Department’s best teacher award for her undergraduate and graduate supervision. Dr. Murray Potter, the education co-ordinator and Dr. Fiona Smaill, the chair, present her with the award.

Congratulations Bowdish lab on our successes!

Way to kill it, like young macrophages on pneumo 😉

Avee Receives a Prestigious CIHR Banting & Best CGS Scholarship

A long overdue congratulations to Avee Naidoo(MSc candidate) for receiving the Frederick Banting and Charles Best Master’s Canada Graduate Scholarship (CGS) from the Canadian Institutes of Health Research (CIHR).

Avee-med

The award funds Avee’s research examining age-associated inflammation, impaired macrophage function and disease susceptibility in the elderly.

Way to go Avee!

Bowdish lab attends PROSPECT study retreat

On June 8-9, members of the Bowdish lab participating in a clinical pilot study with the Canadian Critical Care Trials Group (CCCTG) were able to put down the pipettes and head into the great outdoors for a retreat near Muskoka, Ontario. Aveshni Naidoo, Dessi Loukov, Kyle Novakowski, Dr. Chris Verschoor and Dawn were all excited to attend. Absent: Prospect “A-Team” member Netusha Thevaranjan.

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The Bowdish lab has been in collaboration with a study run by Dr. Deborah Cook termed PROSPECT; Probiotics to prevent Severe Pneumonia and Endotracheal Colonization Trial since March 2013. Since then, the lab made an incredible effort to process hundreds of patient blood samples to measure levels of endotoxin and cytokines as part of a mechanistic sub study.

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The purpose of this retreat was to share and translate knowledge, exchange ideas and gain an understanding of how the many nodes of a multi-center clinical study function together as a team. These goals were certainly achieved early, as Dawn provided an  insightful presentation on what exactly is an endotoxin or a cytokine. Dr. Chris Verschoor followed up with some exciting preliminary data. Administrators, nurses and research coordinators all gained an appreciation for all the hard work members of the Bowdish lab have put into the clinical study thus far. Well done, team!

Following a social hour at the stunning main house, attendees returned to the equally amazing Breezy Ridge Retreat Center for an unforgettable meal, late night games and multiple “life chats”. Many bedtimes were well exceeded.

The following morning saw the administrators, nurses and research coordinators take the floor to discuss topics such as data validation, informed consent and future plans for the clinical study. It was now members of the Bowdish lab turn to learn about all the hard work put in by the clinical and administrative team members.

Following a quick lunch and trek down the 400/401, it was time to return to the lab bench – you never know when new patient samples might be heading our way!

The Bowdish lab would like to thank Dr. Deborah Cook and Dr. Bob Sheppard for sharing their beautiful house and retreat center with us. We’re excited to continue our collaboration and even more excited for what may be on the horizon.

For more information, see: http://www.prospectpilottrial.com/

By Kyle Novakowski

 

Alumnus update: Former thesis student Jessica Wallace accepted for MSc degree

Jessica Wallace (Sept 2013-Apr 2014) was a Life Sciences student who took Dawn’s HTHSCI 4II3 (Advanced Immunology) class. She was such an engaged student that despite being full to the rafters, she became the Bowdish lab’s 7th undergraduate student in the 2013/14 school year. She worked with Dr. Chris Verschoor to study the role of circulating bacterial products in age-associated inflammation. She has been accepted to McMaster’s Medical Sciences Graduate Program and will be working with Dr. Deborah Sloboda (Biochemistry) as an MSc student in Sept 2014. Congratulations Jessica!

Alumnus update: Prashant Bharadwaj accepted to John Hopkins University for graduate school.

Prashant Bharadwaj  (Summer 2013) was an undergraduate from the Indian Institute of Technology who won a MITACS summer studentship to work in the Bowdish lab discovering novel signalling motifs in macrophage scavenger receptors. He will be joining John Hopkins as a graduate student in September 2014. Way to go Prashant!

More funding for Lung Research: The Kayla Baker Award

Last year I had the incredible honour of winning the Pfizer-Lung Association award (+Canadian Lung Association ) research award for my work on preventing pneumonia in older adults. I got to attend the Breathe Gala, a major fundraising effort for the Ontario Lung Association. I was absolutely humbled to be standing beside these three women, Helene Campbell, double lung transplant recipient and idiopathic pulmonary fibrosis patient, Ann Marie Cerato, lung cancer survivor and Kayla Baker who had pulmonary fibrosis and at that time was waiting for a lung transplant. These woman who had or were battling incredibly devastating lung disease were there with a common message “More money for lung research”. I really couldn’t believe how selfless they were, as they were well aware of how slow basic research can be, and how they might not see changes in their lifetime. They knew, as all of us in lung health know, that lung research is underfunded, especially when one considers how much the economic and personal costs are and were using their voices and stories to rally the cause and without more funding health outcomes for people with pulmonary fibrosis, lung cancer or lung infections would be grim. I was inspired by them and have tried my best to take up the cause and become an advocate for lung health.

Dawn standing beside the real heros of the event, Helene Campbell, double lung transplant recipient and idiopathic fibrosis patient, Ann Marie Cerato, lung cancer survivor and Kayla Baker sarcoidosis patient waiting for a lung transplant.

Dawn standing beside the real heros of the event, Helene Campbell, double lung transplant recipient and idiopathic fibrosis patient, Ann Marie Cerato, lung cancer survivor and Kayla Baker sarcoidosis patient waiting for a lung transplant.

I think the whole lung family was devastated when Kayla passed away last year and inspired by her mother Susan’s commitment to continue raising money for lung research.

Below is a bit about Kayla’s story and a link to fund a research award in her name. I was proud to donate and I hope you will consider it to, even $5 or $10 dollars will add up and send Kayla’s message “More funding for lung research.”

About Kayla

Kayla Baker was a true lung warrior…through her unwavering commitment to building awareness of the importance of lung research.

Kayla Baker was diagnosed with Pulmonary Fibrosis, a rare lung disease at the age of 11. This disease is the consequence of chemotherapy she received when she battled cancer, starting at the age of 18 months old. This is when Kayla began a long relationship with SickKids Hospital, becoming a young ambassador for the hospital, helping to generate awareness for organ donation and the need for improvements in medical research and patient care.

A couple years later, we were privileged at the OLA to have Kayla and her mother Susan enter our lives. Kayla became a true lung champion, committing to the cause and speaking publicly about her condition and the need for greater investments in lung research. More recently, Kayla and her mother were featured in a successful national direct mail campaign. She never tired of speaking out on her fight for life in the hopes of helping others. And when Kayla spoke, people listened.

Sadly, Kayla passed away this past Christmas. She leaves behind a memory for all those who have known her of a young girl that personified courage and bravery…and someone that continues to inspire and generate hope.

The Kayla Baker Research Award is being established in her memory.

http://breathingasone.kintera.org/faf/donorReg/donorPledge.asp?supId=0&ievent=1109594&lis=1&kntae1109594=8C885C032AC34294BA69FD22C8CED225&team=

“Comprehensive & simultaneous coverage of lipid and polar metabolites for endogenous cellular metabolomics using HILIC-TOF-MS” 2014. Fei et al. Anal Bioanal Chem.

 

Bowdish-McCarry PhD candidate, Fan Fei, publishes a protocol she created to study the endometabolome of macrophages and microbes in Analytical & Bioanalytical Chemistry. Click the image for the .pdf.
Fei 2014 covershot ABC