Bowdish Lab attended Queen’s Park Lobby Day with the Ontario Lung Association!

Bowdish Lab attended Queen’s Park Lobby Day with the Ontario Lung Association!

On Monday November 30th, the last day of Lung Month, members of the Bowdish Lab joined the Ontario Lung Association to lobby for the Lung Health Act at Queen´s Park. PI Dawn Bowdish and four lab members, Andrea Kellner (visiting PhD candidate), Dessi Loukov (PhD candidate), Kyle Novakowski (PhD candidate) and Justin Boyle (undergraduate), advocated for increased funding for lung research through support of Bill 41: The Lung Health Act. It was a great honour to meet the Speaker of the Legislative Assembly of Ontario, David Levac and talk to him about the importance of lung health. This aim was well received and he encouraged the junior researchers to never stop pursuing their scientific goals. Afterwards the team had the opportunity to explore the stunning architecture and history of Queen´s Park, which first opened in 1860. Later the reception afforded the Bowdish lab the privilege to meet MPPs and organizing members of the Lung Association. One exceptional guest and supporter of the Lung Association is Walter Gretzky, who welcomed people warmly and never tired of giving autographs. Especially inspiring was the prospect of meeting people affected by lung diseases as well as people engaged to directly help them as respiratory educators. This emphasized the importance of research performed in the Bowdish Lab and for whom it is done for. In summary, the day highlighted how research and politics can work together to improve the lives of Ontarians and how democracy works in the context of health.

George Habib from the Ontario Lung Association discusses the importance of the Lung Health Act.

George Habib from the Ontario Lung Association discusses the importance of the Lung Health Act.

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Tammy Villeneuve (OLA), Andrea Kellner, Justin Boyle, MPP Dave Levac, Kyle Novakowski, Dessi Loukov and Dr. Dawn Bowdish meet to discuss the Lung Health Act.

Tammy Villeneuve (OLA), Andrea Kellner, Justin Boyle, MPP Dave Levac, Kyle Novakowski, Dessi Loukov and Dr. Dawn Bowdish meet to discuss the Lung Health Act.

Novemer 12th is World Pneumonia Day – celebrate by getting vaccinated against influenza and pneumococcal pneumonia!

Novemer 12th is World Pneumonia Day – celebrate by getting vaccinated against influenza and pneumococcal pneumonia!


Hear the interview on Metro Morning with Matt Galloway here:

http://www.cbc.ca/news/canada/toronto/programs/metromorning/researchers-find-getting-the-flu-can-lead-to-other-diseases-1.3315848

Read about why older adults should be vaccinated against pneumococcal pneumonia and influenza, as profiled by the CBC here:
http://www.cbc.ca/news/health/flu-vaccines-mcmaster-1.3315511?cmp=rss

and here

http://www.cbc.ca/news/canada/toronto/programs/metromorning/pathologist-deeply-saddened-vaccines-distrust-1.3315893

To hear Dawn discuss the benefits of vaccination for older adults on London AM 960 The Pulse with Devon Peacock (airdate: Nov 13, 2015) click here:
http://www.am980.ca/the-pulse/

To read about the link between dementia and pneumonia:
http://www.atsjournals.org/doi/abs/10.1164/rccm.201212-2154OC#.VkTWTHarRaR

To read about the link between cardiovascular disease and pneumonia
http://jama.jamanetwork.com/article.aspx?articleid=2091304

Work in the Bowdish lab is funded by the Canadian taxpayer through the Canadian Institutes of Health Research, the National Science and Engineering Research Council, and through donations administered by the Ontario Lung Association.

Avee Naidoo recognized for her research by the CIHR Institute of Aging.

As mentioned in an earlier post, Bowdish lab PhD student, Avee Naidoo, won the Fall 2014 CIHR Institute of Aging Anne Martin-Matthews Doctoral Research Prize of Excellence in Research on Aging and is mentioned in the CIHR’s Institute of Aging newsletter!

Avee Naidoo (PhD candidate) wins the Anne Martin-Matthews Doctoral Research Prize of Excellence in Research on Aging!

Congratulations to Avee Naidoo for winning the Anne Martin-Matthews Doctoral Research Prize of Excellence in Research on Aging! Avee’s work focuses on studying the role of the microenvironment on age and how this affects immune function in the elderly. Her research will help us to understand the mechanisms behind the impaired antibacterial function seen in the elderly, as well as lead to earlier prognosis of individuals at risk of chronic age related diseases.

Avee will be presented her award at this year’s Annual Scientific and Educational Meeting of the Canadian Association on Gerontology in Calgary, Alberta! She will also be a guest judge for the Student Poster Competition at the meeting so bring your A game!

Avee-med

 

Review: An introduction to automated flow cytometry gating tools and their implementation

An introduction to automated flow cytometry gating tools and their implementation

Chris Verschoor, Alinia Lelic, Jonathan Bramson & Dawn ME Bowdish

Frontiers in Immunology
Front. Immunol., 27 July 2015 | http://dx.doi.org/10.3389/fimmu.2015.00380

Current flow cytometry (FCM) reagents and instrumentation allow for the measurement of an unprecedented number of parameters for any given cell within a homogenous or heterogeneous population. While this provides a great deal of power for hypothesis testing, it also generates a vast amount of data, which is typically analyzed manually through a processing called “gating.” For large experiments, such as high-content screens, in which many parameters are measured, the time required for manual analysis as well as the technical variability inherent to manual gating can increase dramatically, even becoming prohibitive depending on the clinical or research goal. In the following article, we aim to provide the reader an overview of automated FCM analysis as well as an example of the implementation of FLOw Clustering without K, a tool that we consider accessible to researchers of all levels of computational expertise. In most cases, computational assistance methods are more reproducible and much faster than manual gating, and for some, also allow for the discovery of cellular populations that might not be expected or evident to the researcher. We urge any researcher who is planning or has previously performed large FCM experiments to consider implementing computational assistance into their analysis pipeline.

For access to the .pdf click here.

 

Manuscript: The evolution of the scavenger receptor cysteine-rich domain of the class A scavenger receptors

Do you work out? Cause you’re built like a rock! A rock like Dwayne “The Rock” Johnson! You have an impenetrable body thanks to your complex immune system. So how did you get such a sophisticated immune system?

In the Bowdish lab, we do more than just macrophage biology; we also study the evolution of the immune system! The scavenger receptors are a group of receptors that play an important role in your immune system by binding harmful bacteria. Our most recent publication by Yap et al., looks at how these receptors evolved and how evolution has changed their function. These receptors are found in various forms of life such as sharks, frogs, and mammals, but the function and appearance of these receptors has changed over time. Check out the open access….

The Bowdish lab has a new PhD student! Congrats Avee!

 

 

Avee Naidoo successfully passed her transfer exam today. She now joins the ranks of Fan Fei, Mike Dorrington, Kyle Novakowski, Dessi Loukov, Sara Makaremi, and Pat Schenck as part of the Bowdish lab PhD posse. Well done Avee!

 

Avee-med

Becoming a PhD student in the Bowdish lab is a family affair. Junior lab members  sent their favourite stuffie in to wish Avee luck. It must have worked as she aced it!Becoming a PhD student in the Bowdish lab is a family affair. Junior lab members sent their favourite stuffie in to wish Avee luck. It must have worked as she aced it!

...and a little lab humour. We have both skilled scientists (see picture at bottom) and skilled artists (see whiteboard) in our lab.

…and a little lab humour. We have both skilled scientists (see picture at bottom) and skilled artists (see whiteboard) in our lab.